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Journal of Experimental Neurology
ISSN: 2692-2819
Hooshang Lahooti
University of Sydney, Australia
Featured Article
Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
Featured Article
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models
Featured Article
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
About this Journal
Journal of Experimental Neurology is an international publication primarily dedicated to publish original research and novel findings in the neuroscience field. This journal offers a great opportunity to the neuroscientists to discuss and exchange their ideas and major advances in clinical and experimental neurology. The journal publishes original articles, reviews, editorials, letters, and short communications in all major concepts of experimental neurology.
Articles
Glial Cell and Perineuronal Net Interactions in the Dorsal Striatum of Aged Mice
Elucidating how normal aging increases vulnerability to neurodegeneration remains a major gap in our understanding of disease risk and progression. The dorsal striatum serves as the primary input nucleus of the basal ganglia and is a key region implicated in multiple neurodegenerative diseases (NDDs). In Colon et al. 2025, we examined the impact of normal aging on neuroinflammatory signaling and perineuronal net (PNN) homeostasis within the dorsal striatum.
An Unusual Ion Channel of the TRP Family TRPV6: A Comment on the Connection of TRPV6 and Mucolipidosis Type II
Mutations in a single TRPV6 allele trigger chronic pancreatitis while loss of both alleles is responsible for skeletal dysplasia in newborns. The latter clinical presentation is accompanied by elevated serum levels of the parathyroid hormone, a condition known as transient neonatal hyperparathyroidism (TNHP). In humans, TRPV6 is abundantly expressed in the primary fetal-maternal interface in the placenta, as well as in pancreatic acini and within a few exocrine glands including salivary and lacrimal glands.
Pairwise External Validation of Plasma Biomarker–Based Machine Learning Models for Amyloid PET Prediction: Implications for Calibration and Clinical Utility
Blood-based biomarkers have demonstrated strong performance for identifying cerebral amyloid pathology within individual cohorts. However, their clinical utility depends on portability across populations and assay platforms. The impact of cross-cohort deployment on clinically actionable metrics such as negative predictive value remains insufficiently characterized. We analyzed data from two independent cohorts: the Alzheimer’s Disease Neuroimaging Initiative (n = 885) and the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease study (n = 822).
Commentary: Expanding the Understanding of Gut Microbial Dysbiosis in Alzheimer’s Disease
Alzheimer’s disease (AD) represents a persistent and growing global health challenge. It is a progressive, and largely sporadic neurodegenerative condition characterized not only by a reduction in brain volume and weight but also by widespread and progressive atrophy of the cerebrum. The disease involves substantial loss of neurons, particularly in the hippocampus and the medial temporal lobes, as confirmed through pathological studies.
Resolving Glycosphingosine Isomers by Crown Ether–Assisted Ion Mobility for Neurological Lipidomics
Glycosphingosines are neuroactive lipids whose stereochemical variations are increasingly implicated in neuronal dysfunction and neurodegenerative disease processes. However, their close structural similarity renders stereoisomer-resolved analysis inaccessible to conventional LC–MS approaches, limiting mechanistic interpretation of lipid-associated neuropathology. In previous work, we demonstrated that complexation of glycosphingosine isomers with crown ethers enabled cyclic ion mobility spectrometry to resolve most of the species. Here, we investigate the energetics and structural effects of crown ether binding to interrogate the mechanism of separation enhancement.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Comparing Contrast Agent Enhancement: The Value of Artificial Intelligence/Machine Learning
Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
The Spread of Spectrin in Ataxia and Neurodegenerative Disease
Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Glutaminergic Signaling in the Nucleus Accumbens Modulates the Behavioral Response to Acute and Chronic Methylphenidate
Methylphenidate (MPD) is a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, and is being increasingly misused as a recreational drug and cognitive enhancer
Testing the Efficacy of Minocycline Treatment in an Awake, Female Rat Model of Repetitive Mild Head Injury
Minocycline is being tested in clinical trials for the treatment of stroke and traumatic brain injury. As an antibiotic it reduces microglia activation. Can minocycline be used to treat mild repetitive head injury? To that end, minocycline was tested in a novel, closed-head, momentum exchange model of repetitive mild head injury in female rats impacted while fully awake. Magnetic resonance imaging (MRI) revealed there was no brain damage or contusion attesting to the mild nature of the head impacts in this model.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke
Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.
Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics
Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].
A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans
Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.
In the Mind of the US Olympic Athletes; Longevity Advantage and Its Relation to Nervous System Disorders and Mental Illness
In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts.
About Scientific Archives
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